Related Experiment Video
Updated: May 28, 2026

07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
[Consensus diagnosis and therapy of soft tissue sarcoma]
Thomas Brodowicz1, Gabriele Amann, Andreas Leithner
1Klinische Abteilung für Onkologie, Universitätsklinik für Innere Medizin, Wien, Austria. Thomas.brodowicz@meduniwien.ac.at
Wiener Klinische Wochenschrift
|November 1, 2011
Summary
These consensus guidelines provide Austrian sarcoma specialists with updated recommendations for diagnosing and treating soft tissue sarcomas. They emphasize multidisciplinary care and referral to specialized university centers for improved patient outcomes.
Area of Science:
- Oncology
- Pathology
- Medical Guidelines
Context:
- Soft tissue sarcomas are rare, heterogeneous cancers with evolving understanding.
- International guidelines exist (ESMO, NCCN), but require adaptation for local Austrian practice.
- Advances in pathology, clinical behavior, diagnosis, and treatment necessitate updated guidance.
Purpose:
- To summarize recent advances in soft tissue sarcoma management.
- To provide Austrian-specific recommendations based on local clinical practice and facilities.
- To establish clear, state-of-the-art guidance for sarcoma care in Austria.
Summary:
- Developed by Austrian sarcoma specialists from leading medical universities.
- Addresses diagnosis, clinical behavior, and treatment of soft tissue sarcomas.
- Highlights the interdisciplinary nature and essential multimodal treatment approach.
Impact:
- Recommends referral of all suspected soft tissue sarcoma patients to specialized university centers.
- Advocates for management by a specialist sarcoma multidisciplinary team.
- Aims to enhance clinical practice and improve the quality of care for sarcoma patients in Austria.
Related Concept Videos
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

