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Shared environmental contributions to substance use.

Jessica H Baker1, Hermine H Maes, Kenneth S Kendler

  • 1Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA.

Behavior Genetics
|November 1, 2011
PubMed
Summary
This summary is machine-generated.

Childhood household substance use and parental attitudes significantly influence adult males' substance use. Family environment factors explain a large portion of shared genetic effects for illicit drug use.

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Area of Science:

  • Behavioral Genetics
  • Psychiatry
  • Environmental Health

Background:

  • Substance use disorders are a significant public health concern.
  • Understanding the interplay of genetic and environmental factors in substance use is crucial.
  • Previous research highlights the role of family environment in substance use development.

Purpose of the Study:

  • To investigate the association between childhood household substance use, parental attitudes, and lifetime substance use in adult males.
  • To determine the proportion of shared environmental variance attributable to family environmental factors for illicit drug use.
  • To extend behavior genetic research by identifying specific etiological environmental mechanisms.

Main Methods:

  • Utilized data from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders.
  • Included 1081 monozygotic and 707 dizygotic twins.
  • Employed retrospective life history interviews to gather data on substance use and family environment.
  • Conducted a trivariate Cholesky decomposition using the program Mx to analyze genetic and environmental influences.

Main Results:

  • Family environmental factors significantly accounted for a substantial proportion of shared environmental effects related to illicit drug use.
  • Parental attitudes towards substance use and household substance use during childhood were associated with lifetime substance use in males.
  • The study identified specific etiological environmental mechanisms contributing to substance use.

Conclusions:

  • Family environment plays a critical role in the development of substance use disorders in males.
  • Behavior genetic research can effectively identify specific environmental influences on substance use.
  • Findings underscore the importance of addressing family environmental factors in prevention and intervention strategies for substance use.