Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind the gap: making headway in functional visual loss.

Eye (London, England)·2026
Same author

Incidence of idiopathic intracranial hypertension (IIH) in adults and children: a 14-year population-based study.

Journal of neurology·2026
Same author

Robust and reproducible population receptive field mapping in patients with retinal pathologies.

Eye (London, England)·2026
Same author

A novel CEP78 variant and rod-cone dystrophy in non-consanguineous siblings.

Ophthalmic genetics·2026
Same author

Novel heterozygous UCHL1 variant causing severe optic atrophy and vision loss.

Ophthalmic genetics·2026
Same author

Visual Acuity Alone Is Not Enough: The Need for Multimodal Biomarkers in Dominant Optic Atrophy-Response.

Clinical & experimental ophthalmology·2026

Related Experiment Video

Updated: May 28, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Electroretinogram findings in unilateral optic neuritis.

Clare L Fraser1, Graham E Holder

  • 1Department of Neuro-Ophthalmology, Moorfields Eye Hospital, and Institute of Ophthalmology, University College London, 162 City Road, London, EC1V 2PD, UK.

Documenta Ophthalmologica. Advances in Ophthalmology
|November 1, 2011
PubMed
Summary

Standard electroretinograms (ERGs) showed no significant differences in unilateral optic neuritis (ON). However, pattern ERGs and visual evoked potentials revealed abnormalities in affected eyes, distinguishing ON from multiple sclerosis (MS).

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Related Experiment Videos

Last Updated: May 28, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Unilateral optic neuritis (ON) presents diagnostic challenges, necessitating precise electrophysiological assessment.
  • The electroretinogram (ERG) is crucial for evaluating optic nerve and retinal function.

Purpose of the Study:

  • To investigate electrophysiological findings, particularly electroretinograms (ERGs), in patients with unilateral optic neuritis (ON).
  • To differentiate ON from multiple sclerosis (MS) using pattern electroretinography (PERG) and pattern visual evoked potentials (PVEP).

Main Methods:

  • Retrospective analysis of full-field ERG, PERG, and PVEP in 46 patients with unilateral ON.
  • Comparison of electrophysiological data between affected and fellow eyes, and between patients with and without MS.
  • Adherence to International Society for Clinical Electrophysiology of Vision (ISCEV) standards.

Main Results:

  • Standard ISCEV ERGs showed no significant inter-ocular asymmetry in unilateral ON, irrespective of MS status.
  • Pattern ERG (PERG) demonstrated a significantly reduced N95 component in the affected ON eye.
  • Pattern reversal visual evoked potential (PVEP) revealed significantly prolonged peak time (latency) in the affected ON eye.
  • Significant differences were observed between patients with and without MS.

Conclusions:

  • Standard ERGs are not sensitive to inter-ocular asymmetry in unilateral ON.
  • PERG and PVEP are valuable tools for detecting subtle electrophysiological deficits in ON.
  • Electrophysiological findings may aid in differentiating ON from MS.