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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Biology-oriented synthesis.

Stefan Wetzel¹, Robin S Bon, Kamal Kumar

¹Max-Planck-Institut für Molekulare Physiologie, Abt. Chemische Biologie, Dortmund, Germany.

Angewandte Chemie (International Ed. in English)

|November 1, 2011

Summary

Biology-oriented synthesis identifies bioactive compound classes for chemical biology research and drug discovery. This approach uses structural conservatism to create focused compound libraries, aiding in biological analysis and inspiring new medicinal chemistry programs.

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Area of Science:

Chemical Biology
Medicinal Chemistry
Drug Discovery

Background:

Vast chemical space is challenging to explore comprehensively through synthesis.
Identifying biologically relevant subspaces is crucial for research and drug discovery inspiration.

Purpose of the Study:

To identify optimal compound classes for chemical biology probes and medicinal chemistry inspiration.
To develop methods for navigating chemical space and generating hypotheses for synthesis programs.

Main Methods:

Biology-oriented synthesis (BIOS) leverages structural conservatism in proteins and natural products.
Hierarchical classification of bioactive compounds based on structural relationships and bioactivity.
Utilizing Scaffold Hunter software for navigation and visualization of chemical space.

Main Results:

BIOS-synthesized small molecules show enrichment in bioactivity.
These compounds facilitate the analysis of complex biological phenomena through acute perturbation.
The approach provides novel starting points for drug discovery programs.

Conclusions:

Biology-oriented synthesis is an effective strategy for discovering bioactive compounds.
This method aids in understanding biological systems and inspires medicinal chemistry efforts.
Scaffold Hunter facilitates efficient navigation of chemical space for focused compound library design.