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T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway

Ruiqing Wang1, Huimin Xie, Zhaofeng Huang

  • 1Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|November 1, 2011
PubMed
Summary

T cell factor-1 (TCF-1) promotes the survival of double-positive (DP) thymocytes by increasing RORγt. This TCF-1/RORγt pathway is crucial for regulating DP thymocyte lifespan and T cell development.

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