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Updated: May 28, 2026
12:17
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
[Placenta endocrine function influence on fetal hypothalamo-hypophyseo-thyroid axis]
Tomasz Milewicz1, Magdalena Pulka, Ewa Stochmal
1Klinika Endokrynologii Ginekologicznej Collegium Medicum, Uniwersytetu Jagiellońskiego, Kraków, Polska. milewicz@interia.eu
Przeglad Lekarski
|November 2, 2011
Summary
The placenta significantly influences the developing fetal thyroid axis. Key placental hormones and enzymes like hCG and deiodinases are crucial for thyroid regulation during pregnancy.
Area of Science:
- Endocrinology
- Developmental Biology
- Reproductive Science
Context:
- The placenta plays a vital role in maternal-fetal physiology.
- Thyroid hormone regulation is critical for fetal development.
- Interactions between maternal and fetal systems are complex.
Purpose:
- To review current understanding of placental influence on the fetal hypothalamo-hypophyseo-thyroid axis.
- To elucidate the roles of specific placental factors in this axis.
Summary:
- The placenta impacts the fetal hypothalamo-hypophyseo-thyroid axis through hormones like human chorionic gonadotropin (hCG) and estrogens.
- Enzymes including deiodinases, transferases, and arylsulfatases, along with transthyretin, are involved in thyroid hormone metabolism and transport.
- This review synthesizes contemporary views on these placental contributions.
Impact:
- Provides a comprehensive overview for researchers in reproductive endocrinology.
- Highlights key molecules and pathways for potential therapeutic targets.
- Enhances understanding of fetal thyroid development and its regulation.
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