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Related Experiment Videos

Microconversion between murine H-2 genes integrated into yeast.

C J Wheeler1, D Maloney, S Fogel

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Nature
|September 13, 1990
PubMed
Summary
This summary is machine-generated.

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Short gene conversion, or microconversions, were observed between divergent major histocompatibility complex (MHC) genes in yeast. These findings highlight the role of gene conversion in the evolution of polymorphic gene families.

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Polymorphic multigene families often exhibit sequence homology attributed to short-tract gene conversion.
  • Confirming gene conversion in higher organisms is challenging, as observed conversions, like in the major histocompatibility complex (MHC), are short and lack reciprocal recombination.

Purpose of the Study:

  • To investigate the mechanism of meiotic recombination between divergent nonallelic murine class I genes by integrating them into yeast.
  • To characterize the nature and frequency of gene conversion events between these genes.

Main Methods:

  • Integration of two nonallelic murine class I genes into yeast.
  • Analysis of meiotic recombination events during yeast meiosis.

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Main Results:

  • No crossovers were detected between the integrated MHC genes.
  • Short-tract gene conversions, termed 'microconversions' (1-215 base pairs), occurred in approximately 6% of meioses.
  • One microconversion event was associated with a single base-pair mutation.

Conclusions:

  • Meiotic gene conversion is a significant mechanism shaping sequence patterns in divergent genes.
  • Sequence heterology influences the patterns of gene conversion between nonallelic genes.