Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Spermatogenesis

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...

Sperm Structure and Semen Composition

Sperm Structure and Semen Composition

During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Experimental verification of principal losses in a regulatory particulate matter emissions sampling system for aircraft turbine engines.

Aerosol science and technology : the journal of the American Association for Aerosol Research·2022

Same author

Carica papaya seed extract slows human sperm.

Journal of ethnopharmacology·2019

Same author

Reactive oxygen species impact on sperm DNA and its role in male infertility.

Andrologia·2018

Same author

Evaluation of reference values of standard semen parameters in fertile Egyptian men.

Andrologia·2018

Same author

Calibration of redox potential in sperm wash media and evaluation of oxidation-reduction potential values in various assisted reproductive technology culture media using MiOXSYS system.

Andrology·2018

Same author

Human sperm handling in intracytoplasmic sperm injection processes: In vitro studies on mouse oocyte activation, embryo development competence and sperm oxidation-reduction potential.

Andrologia·2018

Same journal

Correction.

Andrologia·2023

Same journal

The combination of ginger and zinc supplement could improve lead-induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation.

Andrologia·2022

Same journal

Testosterone and lifespan in males: At the right time and the right level.

Andrologia·2022

Same journal

CORRIGENDUM.

Andrologia·2022

Same journal

CORRIGENDUM.

Andrologia·2022

Same journal

Microfluidic devices employing chemo- and thermotaxis for sperm selection can improve sperm parameters and function in patients with high DNA fragmentation.

Andrologia·2022

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

Accurate sperm morphology assessment predicts sperm function.

D Abu Hassan Abu¹, D R Franken, B Hoffman

¹Khartoum Fertility Centre, Khartoum, Sudan. dalyaabu@hotmail.com

|November 2, 2011

Summary

This summary is machine-generated.

Normal sperm morphology is linked to sperm dysfunction, including poor chromatin condensation and DNA integrity. While not the sole fertility indicator, it serves as a valuable marker for underlying issues.

More Related Videos

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

Fluorimetric Techniques for the Assessment of Sperm Membranes

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

Related Experiment Videos

Last Updated: May 28, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

Fluorimetric Techniques for the Assessment of Sperm Membranes

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

Area of Science:

Reproductive Biology
Andrology
Spermatozoa Function

Background:

Sperm morphology is a recognized factor influencing both in vitro and in vivo fertilization.
Assessing sperm functional parameters alongside morphology is crucial for a comprehensive fertility evaluation.

Purpose of the Study:

To investigate the correlation between normal sperm morphology and key sperm functional assays.
To determine the relationship between morphology and zona-induced acrosome reaction (ZIAR), DNA integrity, chromatin condensation, apoptosis, and necrosis.

Main Methods:

Regression analysis was used to assess associations between sperm morphology and functional parameters.
Evaluated were: ZIAR, sperm DNA integrity, chromatin condensation (CMA3 staining), apoptosis, and necrosis.

Main Results:

Normal sperm morphology significantly correlated with higher rates of live acrosome-reacted spermatozoa in ZIAR.
Negative correlations were observed between normal morphology and DNA integrity, chromatin condensation (CMA3+), sperm apoptosis, and necrosis.
Sperm morphology is indicative of underlying sperm dysfunction, including issues with chromatin condensation and DNA integrity.

Conclusions:

Sperm morphology is significantly associated with several sperm functional parameters, reflecting underlying cellular dysfunction.
While not a standalone diagnostic tool, normal sperm morphology is a valuable indicator of male fertility potential and sperm health.