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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Updated: May 28, 2026

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
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Published on: October 6, 2023

Metabonomics-based omics study and atherosclerosis.

Duo-Jiao Wu1, Bi-Jun Zhu, Xiang-Dong Wang

  • 1Biomedical Research Center, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, China. xiangdong.wang@telia.com.

Journal of Clinical Bioinformatics
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

Metabonomics, the study of metabolic responses, helps understand atherosclerosis development. This approach reveals how metabolic disturbances and inflammation contribute to the disease, aiding biomarker discovery.

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Last Updated: May 28, 2026

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
02:55

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue

Published on: October 6, 2023

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
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The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

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Published on: June 12, 2019

Area of Science:

  • Biochemistry
  • Systems Biology
  • Metabolomics

Background:

  • Atherosclerosis arises from dyslipidemia and inflammation, intricately linked to metabolism and diet.
  • Understanding metabolic pathways is crucial for defining mechanisms in pathological alterations.

Purpose of the Study:

  • To review the application of metabonomics in understanding atherosclerosis.
  • To explore the role of metabolic disturbances and inflammation in atherosclerosis initiation and progression.

Main Methods:

  • Metabonomics: quantitative measurement of metabolic responses to stimuli.
  • Integration with proteomics and transcriptomics within a systems biology framework.
  • Review of existing literature on metabonomics in atherosclerosis research.

Main Results:

  • Metabonomics provides insights into the dynamic metabolic changes during atherosclerosis.
  • Identifies potential links between metabolic disturbances, inflammation, and disease development.
  • Highlights the utility of omics studies for biomarker discovery.

Conclusions:

  • Metabonomics is a valuable tool for dissecting the complex mechanisms of atherosclerosis.
  • This approach can disentangle the influences of diet, environment, and lifestyle on disease pathogenesis.
  • Metabonomics-based studies offer significant potential for identifying novel biomarkers.