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Published on: June 15, 2020
Clinical analysis of vascular anomalies: a hospital-based retrospective study of 592 patients in southeast China
Cai-Sheng Ye1, Ling-Xiao Pan, Yong-Bo Huang
1Department of Vascular and Thyroid Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Insights
This study analyzed 592 vascular anomaly cases, finding head and neck involvement most common. Most patients showed favorable outcomes after surgical therapy, highlighting the need for standardized terminology and management.
Area of Science:
- Medical research
- Clinical diagnostics
- Surgical outcomes
Background:
- Vascular anomalies present diagnostic and therapeutic challenges due to confusing terminology and heterogeneity.
- This study retrospectively reviews clinical characteristics, diagnosis, therapies, and outcomes of vascular anomalies in southeast China.
Purpose of the Study:
- To assess clinical characteristics, diagnosis, therapies, and outcomes of patients with vascular anomalies.
- To provide insights into the management and prognosis of these conditions.
Main Methods:
- Retrospective analysis of 592 patients with vascular anomalies (excluding intracranial/visceral involvement).
- Data collected from January 2006 to September 2009 at the First Affiliated Hospital of Sun Yat-sen University.
- Analysis of clinical characteristics, diagnostic methods, therapeutic interventions, and patient outcomes.
Main Results:
- Head and neck region most commonly affected (31.4%).
- Infantile hemangiomas comprised 94.1% of vascular tumors, and venous malformations 41.0% of vascular malformations.
- Surgical therapy was used in 94.2% of patients, with 62.0% cured and 20.8% markedly improved at follow-up.
Conclusions:
- Vascular anomalies are clinically diverse, necessitating clear terminology and management strategies.
- The overall treatment outcome for vascular anomalies is generally favorable, but further research is warranted.
Background:
Vascular anomalies are common and multidisciplinary involved diseases. The greatest impediment to their treatment in the past was their confusing terminology and clinical heterogeneities. This hospital-based retrospective study assessed some clinical characteristics, diagnosis, therapies and outcomes of patients with vascular anomalies in southeast China.
Methods:
A total of 592 vascular anomalies patients (patients with intracranial tissues or viscera involved were excluded), admitted to the First Affiliated Hospital of Sun Yat-sen University from January 2006 to September 2009, were enrolled in the study. Data for clinical characteristics, diagnosis, therapies and outcomes were collected and analyzed.
Results:
Of the 592 patients, the male:female ratios in the vascular tumor group (n = 187) and the vascular malformation group (n = 405) were 1:1.49 and 1:1.06 respectively, with no significant difference between them. The mean onset age of the vascular tumor group was significantly younger than that of the vascular malformation group (p < 0.001). The head and neck were the most commonly (31.4%) involved areas in vascular anomalies. A total of 23.8% of the patients with vascular anomalies had definite symptoms caused by the vascular lesions. In the vascular tumor group, 94.1% of them were infantile hemangiomas. Venous malformation was the most common (41.0%) subtype of vascular malformations. Surgical therapy was undertaken in 94.2% of the patients with vascular anomalies. Of the 519 patients available for the 16 - 58 month follow-up, 322 patients (62.0%) were cured, 108 patients (20.8%) were markedly improved, 57 patients (11.0%) were partially improved, and 32 patients (6.2%) were uncured.
Conclusions:
Vascular anomalies are clinically heterogeneous. While the outcome is generally favorable, further effort should be made to determine the appropriate terminology and management.
