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Published on: January 27, 2023
Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
Shuai Zhao1, Ying-Ying Guo, Ning Ding
1Department of Rheumatism, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China.
Background:
Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis.
Methods:
Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients.
Results:
The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity.
Conclusion:
sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
