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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors
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Canine papillomaviruses.

Christian E Lange1, Claude Favrot

  • 1Dermatology Department, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland. clange@vetclinics.uzh.ch

The Veterinary Clinics of North America. Small Animal Practice
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PubMed
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Canine papillomaviruses cause various skin growths in dogs, including warts and plaques. While most papillomas resolve naturally, diagnosis and preventative vaccines are still needed.

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Published on: December 3, 2013

Use of Interferon-&gamma; Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Area of Science:

  • Veterinary Dermatology
  • Oncology
  • Virology

Background:

  • Papillomaviruses infect epithelial cells, leading to proliferative disorders in various species.
  • Canine papillomaviruses (CPVs) are associated with diverse pathologies, ranging from external warts to internal lesions and potentially squamous cell carcinomas.
  • Infection involves a subclinical phase before visible symptoms manifest.

Purpose of the Study:

  • To review the clinical presentations and natural history of canine papillomavirus infections.
  • To highlight diagnostic considerations and the spontaneous regression patterns of canine papillomas.
  • To discuss the potential for preventative vaccination against canine papillomaviruses.

Main Methods:

  • Literature review of canine papillomavirus infections.
  • Clinical case analysis of papilloma-associated pathologies.
  • Discussion of diagnostic methods and epidemiological data.

Main Results:

  • Canine papillomaviruses induce a spectrum of lesions, including oral papillomatosis, endophytic warts, pigmented plaques, and squamous cell carcinomas.
  • A subclinical period precedes the clinical manifestation of symptoms.
  • Spontaneous regression of most papillomas occurs within months.

Conclusions:

  • Canine papillomavirus infections present with varied clinical signs, necessitating accurate diagnosis.
  • While spontaneous regression is common, therapeutic and preventative strategies remain important.
  • Preventative vaccines are a potential but currently unavailable tool for canine papillomavirus control.