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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
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Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

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Related Experiment Video

Updated: May 28, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Immediate versus as-needed acetaminophen for post-immunisation pyrexia.

B Dhingra1, D Mishra

  • 1Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Maulana Azad Medical College, Delhi, India. drbdhingra@gmail.com

Annals of Tropical Paediatrics
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

Prophylactic acetaminophen after diphtheria-pertussis-tetanus vaccination reduced fever and irritability in the first six hours. However, routine use is not recommended due to similar overall acetaminophen use and potential adverse effects.

Related Experiment Videos

Last Updated: May 28, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Area of Science:

  • Pediatric Medicine
  • Immunology
  • Pharmacology

Background:

  • Routine childhood immunizations, such as diphtheria-pertussis-tetanus (DPT), commonly cause local and systemic adverse events.
  • Antipyretics, particularly acetaminophen, are frequently administered to manage these post-vaccination side effects.
  • The prophylactic use of acetaminophen immediately after vaccination is sometimes recommended.

Purpose of the Study:

  • To investigate the efficacy of prophylactic acetaminophen in mitigating post-vaccination side effects.
  • To assess the impact of immediate post-vaccination acetaminophen administration on fever, irritability, and local reactions.

Main Methods:

  • A prospective, comparative trial involving 167 children aged 1.5 to 24 months undergoing routine immunization.
  • Participants were randomized into two groups: 'immediate' (received acetaminophen post-vaccination) and 'as-needed' (no prophylactic acetaminophen).
  • Outcomes were assessed via telephone interviews, focusing on parent-reported fever, irritability, and local side effects.

Main Results:

  • The 'as-needed' group showed a statistically significant higher incidence of fever and irritability within the first 6 hours post-vaccination (p=0.04).
  • No significant differences were observed between the groups regarding the incidence of local or systemic side effects.
  • The median number of acetaminophen doses required by children in both groups was similar.

Conclusions:

  • Routine prophylactic acetaminophen administration after DPT vaccination effectively reduced fever and irritability in the initial 6 hours.
  • Despite initial symptom reduction, the similar overall acetaminophen dosage required suggests routine prophylactic use may be inappropriate.
  • Consideration of potential adverse effects of routine acetaminophen administration in all infants receiving DPT vaccination is warranted.