Should sevoflurane be used for maintenance of anaesthesia in children?

Adam Duffen1, Andrew Williams

  • 1Department of Anaesthesia, Ealing Hospital, London. adamduffen@yahoo.co.uk

Insights

Sevoflurane offers rapid inhalational anesthesia induction but poses a risk of emergence delirium in children. This condition involves disorientation and hyperactivity, potentially causing harm and delaying recovery.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine

Background:

  • Sevoflurane is favored for inhalational anesthesia induction due to its pleasant odor and rapid onset.
  • Concerns exist regarding sevoflurane's use for maintaining anesthesia in pediatric patients because of emergence delirium.
  • Emergence delirium is characterized by disorientation, perceptual alterations, and hyperactive behavior post-anesthesia.

Purpose of the Study:

  • To evaluate the risks and implications of emergence delirium in children.
  • To analyze the incidence and consequences of emergence delirium following sevoflurane anesthesia.

Main Methods:

  • Literature review on sevoflurane use in pediatric anesthesia.
  • Analysis of studies defining and reporting emergence delirium incidence.
  • Review of documented complications associated with emergence delirium.

Main Results:

  • Emergence delirium incidence ranges from 10% to 80% in pediatric patients.
  • This condition can lead to self-injury or harm to caregivers.
  • Delayed recovery and dislodged medical devices are common consequences.

Conclusions:

  • The risk of emergence delirium necessitates careful consideration when using sevoflurane for pediatric anesthesia maintenance.
  • Understanding and managing emergence delirium is crucial for patient safety and efficient recovery.
  • Further research may be needed to mitigate the incidence of emergence delirium in pediatric anesthesia.

Related Concept Videos

Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...