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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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A Free-breathing fMRI Method to Study Human Olfactory Function
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Olfactory function in patients with ischemic stroke: a pilot study.

Maria Paola Cecchini1, Viola Bojanowski, Ulf Bodechtel

  • 1Neurological, Neuropsychological, Morphological and Movement Sciences Section, Department of Anatomy and Histology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|November 2, 2011
PubMed
Summary
This summary is machine-generated.

This pilot study found that while ischemic stroke patients often perceive smell normally, objective olfactory event-related potential tests reveal deficits on the affected side. This suggests subtle olfactory system damage may not be consciously detected.

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Area of Science:

  • Neurology
  • Neuroscience
  • Otolaryngology

Background:

  • Investigating olfactory function post-ischemic stroke is crucial for understanding brain-olfactory pathways.
  • Previous research has not fully elucidated olfactory perception changes in patients with specific stroke locations.

Observation:

  • Three unselected, cooperative ischemic stroke patients participated in the study.
  • Olfactory testing included the Sniffin' Sticks test and olfactory event-related potentials (oERPs).

Findings:

  • Psychophysical testing indicated normosmia or mild hyposmia in stroke patients, aligning with age-adjusted norms.
  • oERPs revealed absent responses or prolonged latencies on the stroke-affected side.
  • Objective electrophysiological measures detected olfactory pathway lesions not apparent in subjective testing.

Implications:

  • Objective olfactory testing can reveal deficits in ischemic stroke patients even when subjective smell perception is normal.
  • oERPs may serve as a sensitive tool for detecting subtle neurological damage affecting olfactory pathways.
  • Further research with larger cohorts is warranted to confirm these findings and explore clinical relevance.