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Related Concept Videos

Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...
Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 28, 2026

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist

Published on: April 25, 2018

How to connect an IgE-driven response with CTL activity?

Barbara Platzer1, Eleonora Dehlink, Shannon J Turley

  • 1Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Enders 630, Boston, MA 02115, USA.

Cancer Immunology, Immunotherapy : CII
|November 2, 2011
PubMed
Summary

This study explores if immunoglobulin E (IgE) can trigger cytotoxic T-lymphocyte (CTL) responses via dendritic cell (DC) cross-presentation. Researchers investigated IgE Fc receptors (FcεRI and FcεRII) as potential pathways for IgE-mediated antigen uptake and CTL induction.

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Last Updated: May 28, 2026

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07:48

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12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

Area of Science:

  • Immunology
  • Cancer Immunotherapy
  • Cell Biology

Background:

  • Cell-based immune therapy aims to induce tumor-specific cytotoxic T-lymphocyte (CTL) responses.
  • Dendritic cells (DCs) are crucial for initiating CTL responses through antigen cross-presentation.
  • Immunoglobulin G (IgG) immune complexes facilitate efficient CTL induction via Fc-gamma receptors on DCs.

Purpose of the Study:

  • To investigate the potential of immunoglobulin E (IgE) in mediating antigen cross-presentation by DCs for CTL induction.
  • To explore the role of human IgE Fc receptors (FcεRI and FcεRII) in IgE-mediated antigen uptake for cross-presentation.

Main Methods:

  • Discussion of existing literature on IgE Fc receptors and DC cross-presentation pathways.
  • Analysis of the potential mechanisms for IgE-mediated antigen sampling by DCs.
  • Theoretical exploration of IgE's role in initiating adaptive immune responses.

Main Results:

  • Dendritic cells (DCs) utilize Fc-gamma receptors for IgG-mediated cross-presentation to induce CTLs.
  • The study discusses the potential of IgE Fc receptors, FcεRI and FcεRII, to mediate antigen uptake for IgE-based cross-presentation.
  • A hypothetical IgE-mediated cross-presentation pathway is proposed.

Conclusions:

  • IgE-mediated cross-presentation could offer a novel mechanism for linking IgE-driven responses to CTL activity.
  • This pathway presents a potential new avenue for cancer immunotherapy strategies.
  • Further research is warranted to validate the functional role of IgE in DC cross-presentation and CTL induction.