Related Experiment Video

Updated: May 28, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

CD95-mediated cell signaling in cancer: mutations and post-translational modulations

Sébastien Tauzin1, Laure Debure, Jean-François Moreau

  • 1Université Rennes, France.

Cellular and Molecular Life Sciences : CMLS
|November 2, 2011
PubMed

Insights

CD95 (Fas) is a death receptor crucial for immune response. While often considered a tumor suppressor, it can also promote inflammation and cancer, highlighting its complex roles.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Apoptosis is vital for tissue homeostasis, immune responses, and development.
  • CD95 (Fas) is a TNF-R superfamily member functioning as a death receptor.
  • CD95L, its ligand, eliminates transformed and infected cells via T-lymphocytes and NK cells.

Purpose of the Study:

  • To review the dual functions of CD95.
  • To discuss the contradictory roles of CD95 in disease and regeneration.

Main Methods:

  • Literature review of CD95 functions.
  • Analysis of CD95's role in immune surveillance and cancer.
  • Examination of non-apoptotic CD95 signaling pathways.

Main Results:

  • CD95 mediates apoptosis and acts as a tumor suppressor in many cancers.
  • Loss-of-function mutations in CD95 confer resistance to apoptosis.
  • CD95 signaling can promote inflammation, carcinogenesis, and tissue regeneration.

Conclusions:

  • CD95 exhibits context-dependent functions.
  • Its role as a tumor suppressor is challenged by its pro-inflammatory and pro-carcinogenic activities.
  • Further research is needed to understand the complex signaling of CD95.

More Related Videos

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...