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[Inflammation in chronic kidney disease: the role of cytokines]

Heloisa R Vianna1, Cristina Maria Bouissou Morais Soares, Marcelo S Tavares

  • 1Universidade Federal de Minas Gerais.

Jornal Brasileiro De Nefrologia
|November 2, 2011
PubMed

Insights

Inflammation plays a key role in chronic kidney disease (CKD) progression. Cytokines and chemokines are implicated, and targeting the immune-inflammatory response may offer new therapeutic strategies for CKD.

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Context:

  • Chronic kidney disease (CKD) is a growing global health concern with significant morbidity and mortality.
  • Obesity, hypertension, and diabetes mellitus are established CKD risk factors.
  • Emerging evidence highlights the critical role of inflammation in CKD pathogenesis.

Purpose:

  • To review the scientific literature on the involvement of inflammation in CKD.
  • To specifically examine the effects of cytokines and chemokines in CKD.
  • To explore the potential of modulating immune-inflammatory responses for CKD treatment.

Summary:

  • Inflammation is a significant pathophysiological factor in CKD.
  • Various cytokines and chemokines are detected in early CKD stages and linked to complications.
  • Drug classes like ACE inhibitors, statins, and cytokine receptor antagonists may influence inflammatory mediators and renal injury.

Impact:

  • Understanding the inflammatory basis of CKD can lead to novel therapeutic targets.
  • Modulating the immune-inflammatory response presents a promising avenue for CKD management.
  • This review consolidates evidence on inflammation's role, guiding future research and clinical practice.

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