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Updated: May 28, 2026
A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
Published on: September 23, 2014
Tissue and soluble biomarkers in breast cancer and their applications: ready to use?
Marco Danova1, Sara Delfanti, Mariangela Manzoni
1Internal Medicine and Medical Oncology Department, Ospedale Civile di Vigevano, Vigevano (Pavia) I-27029, Italy. marco_danova@ospedali.pavia.it
Abstract:
Breast cancer therapies are in continuous evolution: From surgery to hormonal therapy, from classical and new combined chemotherapies to emerging targeted agents of recent introduction to the clinic. The attempt to personalize the best treatment for each patient is driven by efficacy and safety parameters and tumor biology investigations of markers for aggressiveness and response to treatment. The plethora of targeted therapies has provided momentum for the quest to better understand not only target mechanisms of action, but also tumor behavior. Moreover, how to monitor response to these agents is crucial today to achieve better resource-sharing and to find cheaper, less invasive, and standardized detection techniques for clinically validated biomarkers. In this report, we briefly summarize data on the major tissue and soluble biomarkers focusing on their actual use in daily practice, as well as their emerging role and possible future applications in breast cancer treatment.
Insights
Breast cancer treatment is evolving with targeted therapies. This review summarizes key biomarkers for personalized treatment, monitoring response, and future applications in clinical practice.
Area of Science:
- Oncology
- Biomarker Research
- Personalized Medicine
Background:
- Breast cancer therapy is rapidly advancing beyond traditional methods.
- Personalized treatment selection relies on tumor biology and predictive markers.
- Understanding targeted therapy mechanisms and tumor response is critical.
Purpose of the Study:
- To review major tissue and soluble biomarkers in breast cancer.
- To focus on biomarkers' current clinical use and future potential.
- To discuss monitoring treatment response and developing new detection techniques.
Main Methods:
- Literature review of current and emerging breast cancer biomarkers.
- Analysis of biomarker utility in treatment selection and response monitoring.
- Focus on practical applications and future research directions.
Main Results:
- Identified key tissue and soluble biomarkers for breast cancer management.
- Highlighted the role of biomarkers in personalizing therapy and predicting response.
- Discussed the need for standardized, less invasive biomarker detection methods.
Conclusions:
- Biomarkers are essential for advancing personalized breast cancer treatment.
- Further research is needed to optimize biomarker use and monitoring techniques.
- Future applications of biomarkers promise improved efficacy and patient outcomes.
