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Resistance pattern of ciprofloxacin against different pathogens
Oman Medical Journal
|November 2, 2011
Summary
Antimicrobial resistance to ciprofloxacin is increasing among common pathogens like Escherichia coli and Klebsiella pneumoniae. This study highlights the urgent need for surveillance to monitor resistance patterns and guide antibiotic use.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Ciprofloxacin is a widely used broad-spectrum antibiotic.
- Antimicrobial resistance is a significant global health concern.
- Monitoring resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To conduct surveillance of ciprofloxacin resistance in common clinical pathogens.
- To investigate the current status of antimicrobial resistance against ciprofloxacin.
Main Methods:
- Collected 524 clinical isolates: Escherichia coli, Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
- Isolates were collected from January 2008 to February 2009 in Karachi, Pakistan.
- In-vitro antimicrobial activity was assessed using the Disc Diffusion Method (Kirby-Bauer test).
Main Results:
- Ciprofloxacin resistance varied among pathogens: E. coli (27.02%), S. aureus (21.95%), S. typhi (16.66%), K. pneumoniae (72.22%), P. aeruginosa (44.44%).
- High resistance rates were observed for Klebsiella pneumoniae and Pseudomonas aeruginosa.
Conclusions:
- Clinical isolates show emerging resistance to ciprofloxacin, likely due to irrational use.
- Continuous surveillance is essential to track antimicrobial resistance in pathogens.
- This data underscores the need for judicious antibiotic stewardship.
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