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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: May 28, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

[Canine atopic dermatitis].

Emmanuel Bensignor1

  • 1Clinique Vétérinaire F-35510 Rennes-Cesson, Centre Hospitalier Vétérinaire F-75003 Paris. emmanuel.bensignor@wanadoo.fr

Bulletin De L'Academie Nationale De Medecine
|November 3, 2011
PubMed
Summary

Canine atopic dermatitis, a common inflammatory skin condition in dogs, shares similarities with human atopic dermatitis. This makes dogs a valuable model for studying the human disease and developing new treatments.

Area of Science:

  • Veterinary Dermatology
  • Immunology
  • Comparative Pathology

Context:

  • Canine atopic dermatitis (cAD) affects up to 10% of dogs aged 1-3 years.
  • Characterized by distinct clinical signs, cAD diagnosis is primarily clinical.
  • Treatment for cAD is often complex and challenging.

Purpose:

  • To highlight canine atopic dermatitis as a relevant disease model.
  • To explore the similarities between canine and human atopic dermatitis.
  • To provide a foundation for comparative research in atopic dermatitis.

Summary:

  • Canine atopic dermatitis presents with typical clinical signs in young dogs.
  • Diagnosis relies heavily on clinical presentation.
  • The disease exhibits significant pathogenetic, clinical, and therapeutic parallels with human atopic dermatitis.

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

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Last Updated: May 28, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Impact:

  • Establishes canine atopic dermatitis as a valuable preclinical model for human atopic dermatitis research.
  • Facilitates comparative studies to elucidate disease mechanisms.
  • Informs the development of novel therapeutic strategies for both canine and human patients.