Related Experiment Video

Updated: May 28, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Predictive factor of severe renal involvement in children with Henoch-Schoenlein purpura

Wanida Limpongsanurak1, Chookiet Kietkajornkul, Srisupalak Singalavanija

  • 1Dermatology Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University Bangkok, Thailand. limpong7@hotmail.com

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|November 3, 2011
PubMed

Insights

Abnormal urinalysis in children with Henoch-Schonlein purpura (HSP) predicts severe kidney involvement. Early steroid treatment for abdominal pain did not prevent this complication.

Area of Science:

  • Pediatrics
  • Nephrology
  • Rheumatology

Background:

  • Henoch-Schonlein purpura (HSP) is a common childhood vasculitis.
  • Renal involvement is a significant complication of HSP, potentially leading to severe kidney disease.
  • Identifying early predictors of severe renal involvement is crucial for timely intervention.

Purpose of the Study:

  • To determine clinical and laboratory predictors of severe renal involvement in pediatric HSP.
  • To evaluate the efficacy of early systemic corticosteroid administration in preventing severe renal complications.

Main Methods:

  • Prospective data collection of clinical manifestations and laboratory findings in children diagnosed with HSP.
  • Analysis of 168 pediatric cases over a 5-year period (2003-2007).
  • Statistical analysis to identify significant predictive factors for severe renal involvement.

Main Results:

  • Abnormal urinalysis (microscopic hematuria or proteinuria) at diagnosis was a highly significant predictor (p < 0.001) of severe renal involvement.
  • Severe renal involvement was observed in 6.6% of the studied pediatric population.
  • Early systemic corticosteroid treatment for severe abdominal pain did not show a statistically significant difference in preventing severe renal involvement.

Conclusions:

  • Abnormal urinalysis on the day of diagnosis is the sole identified predictive factor for severe renal involvement in pediatric HSP.
  • Early corticosteroid therapy for abdominal pain does not appear to prevent the development of severe kidney complications in HSP.
  • Urinalysis serves as a vital tool for risk stratification in children with Henoch-Schonlein purpura.
Abstract

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...