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Updated: May 28, 2026

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors
Published on: December 3, 2013
[Origin and evolution of canine parvovirus--a review]
Jianjun Zhao1, Xijun Yan, Wei Wu
1Division of Preventive Veterinary Medicine, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Jilin 132109, China. jianjunzhao2004@yahoo.com.cn
Abstract:
Canine parvovirus (CPV-2), first recognized in 1978 as a new pathogen of dogs, was probably derived from a very closely related virus in cats, feline panleukopaenia virus (FPLV) or a closely related carnivore parvovirus (FPLV-like virus). CPV-2 is responsible for either myocarditis or fatal gastroenteritis in pups with high morbidity and mortality. Shortly after its emergence, CPV-2 has become endemic in the global dog population. The original CPV-2 continued to evolve, and was subsequently replaced by three different but closely related antigenic variants, designated CPV-2a, CPV-2b and CPV-2c, which now coexist in dog populations worldwide. The genetic and antigenic variation in CPV-2 also correlated with changes in the host range and tissue tropisms of the virus. Here, we reviewed variation and evolution of CPV-2 in past 30 years and discussed CPV-2 as an important model to study virus evolution.
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