Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone induction by osteogenin and bone morphogenetic proteins.

A H Reddi1, N S Cunningham

  • 1Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.

Biomaterials
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction notice to "Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis" [Osteoarthr Cartil 20 (2012) 446-450].

Osteoarthritis and cartilage·2020
Same author

Tribological altruism: A sacrificial layer mechanism of synovial joint lubrication in articular cartilage.

Journal of biomechanics·2012
Same author

Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis.

Osteoarthritis and cartilage·2012
Same author

The role of lubricant entrapment at biological interfaces: reduction of friction and adhesion in articular cartilage.

Journal of biomechanics·2011
Same author

Dependence of nanoscale friction and adhesion properties of articular cartilage on contact load.

Journal of biomechanics·2011
Same author

Effects of TGF-β1 on alternative splicing of Superficial Zone Protein in articular cartilage cultures.

Osteoarthritis and cartilage·2010
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
See all related articles

Bone induction involves stem cell chemotaxis, proliferation, and differentiation, primarily through endochondral ossification. Osteogenin and bone morphogenetic proteins initiate this process, with other growth factors potentially promoting its maintenance.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Bone induction is a complex biological process essential for skeletal development and repair.
  • It involves the coordinated actions of various cell types and signaling molecules.
  • Endochondral ossification is the primary mechanism for bone formation during this process.

Purpose of the Study:

  • To elucidate the key molecular regulators and phases of bone induction.
  • To identify the roles of specific growth factors in initiating, promoting, and maintaining bone formation.
  • To provide a framework for understanding and potentially manipulating bone regeneration.

Main Methods:

  • Review and synthesis of existing literature on bone induction.
  • Identification of critical signaling pathways and cellular events.

Related Experiment Videos

  • Analysis of the functions of specific growth factors, including osteogenin and bone morphogenetic proteins.

    • Main Results:

    • Bone induction proceeds through initiation, promotion, and maintenance phases.
    • Osteogenin and bone morphogenetic proteins are crucial for initiating bone induction.
    • Platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-beta), insulin-like growth factors (IGF), and fibroblast growth factor (FGF) may play roles in promotion and maintenance.

    Conclusions:

    • Bone induction is a tightly regulated, multi-step process.
    • Specific growth factors, particularly osteogenin and bone morphogenetic proteins, are central to initiating bone formation.
    • A broader range of growth factors contribute to the progression and sustenance of induced bone.