Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol

Area of Science:

• Neurology
• Neuroscience
• Public Health

Background:

• Mild stroke survivors often experience persistent and increasing residual damage years post-event.
• Approximately 45% of stroke victims face long-term disability.
• Understanding factors driving post-stroke decline is crucial for developing effective interventions.

Purpose of the Study:

• To test the hypothesis that combined biochemical, neuroimaging, genetic, and psychological data predict post-stroke disability and decline.
• To identify key markers associated with long-term neurological and cognitive deterioration.
• To inform the development of targeted therapeutic strategies for stroke recovery.

Main Methods:

• The Tel-Aviv Brain Acute Stroke Cohort (TABASCO) study is a prospective cohort study.
• Recruiting ~1125 first-ever mild-moderate stroke patients.
• Evaluating associations between acute-phase markers (demographic, psychological, inflammatory, biochemical, neuroimaging, genetic) and long-term outcomes.

Main Results:

• This section is for results, which are not yet available in the provided abstract.

Conclusions:

• This study comprehensively examines the long-term outcomes of mild-moderate strokes.
• The prospective design will yield quantitative data on stroke recurrence, vascular events, and cognitive/functional decline.
• Identifying associated factors may lead to more effective therapeutic approaches for post-stroke recovery.