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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

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Related Experiment Video

Updated: May 28, 2026

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

Published on: September 6, 2017

Watching the fetal brain at 'rest'.

V Schöpf1, G Kasprian, P C Brugger

  • 1Department of Radiology, Division of Neuro- and Musculoskeletal Radiology, Medical University of Vienna, Austria. veronika.schoepf@meduniwien.ac.at

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|November 3, 2011
PubMed
Summary

Resting-state networks (RSNs) are detectable in fetuses as early as 20 weeks gestational age. This study demonstrates the feasibility of using resting-state functional magnetic resonance imaging (fMRI) to investigate fetal brain development in utero.

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Last Updated: May 28, 2026

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Functional magnetic resonance imaging (fMRI) provides insights into human brain network spatiotemporal distribution.
  • The fetal brain exhibits neurophysiological properties enabling spontaneous activity generation.

Purpose of the Study:

  • To determine the feasibility of investigating fetal intrinsic brain network maturation from 20 weeks gestational age.
  • To combine resting-state fMRI with independent component analysis (ICA) for fetal brain analysis.

Main Methods:

  • Acquired functional images from 16 healthy fetuses (20-36 weeks gestational age) using 1.5T fMRI.
  • Preprocessed images included motion correction and brain extraction.
  • Analyzed images using single-subject ICA to identify intrinsic brain networks.

Main Results:

  • Visualized bilateral occipital network and medial/lateral prefrontal activity patterns (Brodmann areas 9-11).
  • Identified predominantly right or left hemispheric lateralized networks in superior temporal cortical regions (Brodmann areas 22 and 39).
  • Observed frequency oscillations within the 0.01-0.06Hz range for all identified networks.

Conclusions:

  • Resting-state networks (RSNs) are shaped and detectable in the human fetus in utero.
  • Future resting-state fMRI studies in fetuses can enable developmental brain activity monitoring.
  • This research offers insights into early brain function and development.