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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

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Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: May 28, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Food allergy and complementary feeding.

Wayne G Shreffler1, Marcella Radano

  • 1Food Allergy Center, Divisions of Allergy and Gastroenterology, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Nestle Nutrition Workshop Series. Paediatric Programme
|November 3, 2011
PubMed
Summary
This summary is machine-generated.

Delayed introduction of allergenic foods may not protect against atopic disease and could be harmful. Decisions on infant feeding should consider overall health, not just allergy prevention.

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Published on: September 14, 2018

Area of Science:

  • Immunology
  • Pediatric Nutrition
  • Allergy Research

Background:

  • Early studies suggested delaying allergenic foods (cow's milk, egg, nuts) protected against atopic disease.
  • Despite these recommendations, food allergy prevalence has continued to increase.
  • Current understanding of food allergy development and its relation to feeding practices has evolved.

Purpose of the Study:

  • To review the evolving evidence on the relationship between complementary feeding and atopic disease development.
  • To assess the impact of timing of allergenic food introduction on IgE sensitization and atopic dermatitis.
  • To inform current feeding recommendations based on the latest scientific understanding.

Main Methods:

  • Review of observational studies on complementary feeding and atopic outcomes.
  • Extrapolation from immunotherapy trials in allergy management.
  • Analysis of animal models of mucosal immunity.

Main Results:

  • Mounting evidence suggests delayed introduction or avoidance of allergenic foods is neutral or detrimental to atopic outcomes.
  • Observational data contradicts earlier findings on protective effects of food delay.
  • IgE sensitization and atopic dermatitis development are complexly related to food introduction timing.

Conclusions:

  • Delayed introduction of common allergenic foods is not supported by current evidence for preventing atopic disease.
  • Further high-quality research is needed to clarify the precise relationship.
  • Nutritional decisions during complementary feeding should encompass broader health considerations beyond allergy prevention.