Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

Diversity in Cell Signaling Responses

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition.

iScience·2024

Same author

Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.

eLife·2024

Same author

The developmental basis for scaling of mammalian tooth size.

Proceedings of the National Academy of Sciences of the United States of America·2023

Same author

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.

Proceedings of the National Academy of Sciences of the United States of America·2022

Same author

PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents.

Cell reports·2022

Same author

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.

International journal of cancer·2018

Search research articles

Related Experiment Video

Updated: May 28, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

Igf-I signaling and effects on longevity.

Martin Holzenberger¹

¹INSERM UMR 938, Saint-Antoine Hospital, and University Pierre and Marie Curie, Paris, France.

Nestle Nutrition Workshop Series. Paediatric Programme

|November 3, 2011

Summary

Insulin and IGF signaling pathways impact lifespan across species. Neuroendocrine mechanisms, diet, and genetic factors like FOXO3A influence aging and longevity, with implications for human health.

Area of Science:

Gerontology
Neuroendocrinology
Metabolic Research

Background:

Insulin and insulin-like growth factor (IGF) signaling pathways are crucial regulators of survival and lifespan in diverse animal models.
These pathways influence mammalian lifespan through neuroendocrine mechanisms, energy metabolism, and stress resistance.
Postnatal nutrition significantly impacts the somatotropic axis and growth hormone secretion, affecting cardiovascular and metabolic health.

Purpose of the Study:

To explore the role of insulin and IGF signaling in regulating lifespan and aging processes.
To investigate the neuroendocrine mechanisms, metabolic control, and stress resistance associated with these pathways.
To examine the influence of early-life nutrition on neuroendocrine development and its relation to aging.

Main Methods:

More Related Videos

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Related Experiment Videos

Last Updated: May 28, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Review of existing literature on insulin/IGF signaling, lifespan, and aging.
Analysis of studies on neuroendocrine control of longevity in mammals.
Examination of genetic factors, including FOXO3A and IGF-IR, associated with human longevity.

Main Results:

Brain IGF-I receptor and IRS2 are identified as key regulators of mammalian lifespan.
Insulin receptor substrate molecules play a downstream role in lifespan extension.
Early postnatal diet influences somatotropic axis development and growth hormone secretion plasticity.
FOXO3A variants and IGF-IR mutations are linked to extreme longevity in humans.

Conclusions:

Insulin and IGF signaling pathways are fundamental to aging and longevity across species.
Neuroendocrine pathways, influenced by nutrition and genetics, are critical targets for understanding and potentially modulating lifespan.
Further research into these pathways may offer insights into age-related diseases and interventions for healthy aging.