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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The association between different monocyte subsets and coronary collateral development.
Uğur Arslan1, İbrahim Kocaoğlu, Mesude Yılmaz Falay
1Department of Cardiology, Türkiye Yüksek İhtisas Education and Research Hospital, Ankara, Turkey. ugurarslan5@yahoo.com
Coronary Artery Disease
|November 3, 2011
Summary
Increased CD14++CD16- monocytes are linked to better coronary collateral development in stable coronary artery disease patients. This finding highlights a potential biomarker for assessing collateralization and guiding future research.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biomarkers
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Collateral circulation plays a crucial role in mitigating ischemic damage in CAD.
- Previous studies suggest a link between monocyte counts and collateral development.
Purpose of the Study:
- To investigate the association between specific monocyte subsets and coronary collateral development.
- To determine if CD14++CD16- and CD14+CD16+ monocyte levels correlate with good or poor collateralization in CAD patients.
Main Methods:
- A cohort of 105 patients with significant coronary artery stenosis was analyzed.
- Coronary collateral development was assessed using the Cohen-Rentrop grading method.
- Monocyte subsets (CD14++CD16- and CD14+CD16+) were quantified via cytometric analysis.
Main Results:
- Patients with good collateral development had significantly higher overall monocyte counts.
- Circulating CD14++CD16- monocyte levels were markedly elevated in the good collateral group.
- Multivariate analysis confirmed CD14++CD16- monocytes as an independent predictor of good collateralization.
Conclusions:
- This study is the first to demonstrate a significant association between elevated CD14++CD16- monocyte levels and enhanced coronary collateral development.
- CD14++CD16- monocytes may serve as a valuable biomarker for assessing collateral capacity in CAD.
- Further research is warranted to elucidate the precise mechanisms underlying monocyte subset involvement in collateralization.
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