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Tumor vascular biomarkers: new opportunities for cancer diagnostics

Chunsheng Li1, Dimitra Sasaroli, Xiang Chen

  • 1Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA.

Cancer Biomarkers : Section a of Disease Markers
|November 3, 2011
PubMed

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...