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Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic

Jayantee Kalita1, Bindu I Somarajan, Bishwanath Kumar

  • 1Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. jayanteek@yahoo.com

Disease Markers
|November 3, 2011
PubMed

Insights

Phosphodiesterase (PDE4D) gene polymorphism is linked to ischemic stroke. Specific PDE4D genotypes correlate with abnormalities in extracranial and intracranial MR angiography, suggesting a genetic basis for stroke susceptibility.

Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Research

Background:

  • Ischemic stroke shows ethnic variations in MR angiography (MRA) abnormalities, with extracranial (ECMRA) more common in Caucasians and intracranial (ICMRA) in Asians.
  • These ethnic differences may suggest an underlying genetic predisposition.
  • Phosphodiesterase (PDE) enzymes, particularly PDE4D, are implicated in inflammatory processes relevant to atherosclerosis.

Purpose of the Study:

  • To investigate the association between phosphodiesterase (PDE4D) gene polymorphisms and MRA findings in patients with ischemic stroke.
  • To explore potential genetic factors influencing the pattern of cerebrovascular atherosclerosis.

Main Methods:

  • A study cohort of ischemic stroke patients who underwent MRA was analyzed.
  • Severity of atherosclerotic stenosis on MRA was classified using NASCET criteria.
  • Polymerase chain reaction (PCR) was used to genotype PDE4D gene polymorphisms (SNP 32, 83, and 87) in patients and 188 controls.

Main Results:

  • MRA abnormalities were observed in 77% of ischemic stroke patients.
  • The CC genotype of PDE4D83 was significantly more frequent in patients with ischemic stroke compared to controls (OR 3.38, P=0.001).
  • The TT genotype of PDE4D87 was associated with a higher frequency of ICMRA abnormalities (20%) compared to normal ICMRA (2%).

Conclusions:

  • The PDE4D83 CC genotype is associated with an increased risk of ischemic stroke.
  • The PDE4D87 TT genotype may be linked to intracranial cerebrovascular abnormalities.
  • Further research is needed to confirm the role of PDE4D87 in atherosclerosis.

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