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Related Experiment Video

Updated: May 28, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy
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A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

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How to avoid postoperative liver failure: a novel method.

Eduardo de Santibañes1, Fernando A Alvarez, Victoria Ardiles

  • 1Liver Transplant Unit & General Surgery Service, Hospital Italiano de Buenos Aires, Juan D. Perón 4190, C1181ACH, Buenos Aires, Argentina. eduardo.desantibanes@hospitalitaliano.org.ar

World Journal of Surgery
|November 3, 2011
PubMed
Summary
This summary is machine-generated.

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A novel surgical technique combining in-situ liver transection and portal vein ligation rapidly increases future liver remnant (FLR) size. This approach safely enables complex liver resections, preventing postoperative liver failure (PLF) in patients with unresectable liver disease.

Area of Science:

  • Hepatobiliary surgery
  • Surgical oncology
  • Liver regeneration

Background:

  • Postoperative liver failure (PLF) is a critical complication following extensive liver resections.
  • Managing patients with initially unresectable liver disease due to insufficient future liver remnant (FLR) poses a significant challenge.

Purpose of the Study:

  • To introduce and evaluate an innovative surgical technique for patients with locally unresectable liver tumors.
  • To assess the efficacy of in-situ liver transection with right portal vein ligation in promoting FLR hypertrophy.
  • To determine the safety and feasibility of this approach in preventing PLF.

Main Methods:

  • The study involved three patients with unresectable liver tumors (colorectal metastases or hilar cholangiocarcinoma).

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Last Updated: May 28, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy
06:45

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

Published on: January 19, 2024

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

  • A novel technique of in-situ liver transection combined with right portal vein ligation was performed.
  • Volumetric CT scans were used to assess FLR hypertrophy post-intervention.

    • Main Results:

    • Significant FLR hypertrophy (40-80%) was observed within six days after the initial procedure.
    • All three patients successfully underwent completion surgery (right hepatectomy or trisectionectomy) without developing PLF.
    • Patients experienced a mean hospital stay of 16 days and remained disease-free at a two-month follow-up.

    Conclusions:

    • The described technique significantly enhances liver regeneration, exceeding results from portal vein occlusion alone.
    • This approach offers a promising solution for managing primarily unresectable liver disease, enabling a two-stage resection within a single hospital stay.
    • Further research is warranted to validate long-term outcomes and elucidate the mechanisms of enhanced liver regeneration.