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Related Concept Videos

Composition of Blood Plasma01:24

Composition of Blood Plasma

Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins, binding to...
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Role of Proteins in the Human Body01:28

Role of Proteins in the Human Body

Proteins are the building block of life. They are also  the most abundant macromolecules with as many diverse roles in the body. They are part of many structural components that provide unique shapes and structures to animal cells, tissues, and organs. In addition, they also act as biological catalysts and carry out several anabolic and catabolic reactions. Notably, some proteins are chemical messengers and regulate many critical processes, such as metabolism, growth, and development. They are...
What are Proteins?01:55

What are Proteins?

Overview
What are Proteins?01:28

What are Proteins?

Proteins are polymers of amino acids linked together by peptide bonds. Proteins and polypeptides are interchangeably used to refer to long chains of amino acids. However, polypeptides have a molecular weight of fewer than 10,000 daltons, while proteins have greater molecular weight.  Polypeptides with less than 20 amino acids are called oligopeptides or simply peptides. Interactions among the constituent amino acid side chains of proteins help them fold into a stable 3-dimensional structure...
What are Proteins?01:55

What are Proteins?

Overview

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Addition of autologous stem-cell transplantation to an ibrutinib-containing first-line treatment in patients aged 18-65 years with mantle cell lymphoma (TRIANGLE): 4·5-year follow-up of a three-arm, randomised, open-label, phase 3 superiority trial of the European MCL Network.

Lancet (London, England)·2026
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Positron Emission Tomography-Guided Brentuximab Vedotin, Etoposide, Cyclophosphamide, Doxorubicin, Dacarbazine, and Dexamethasone in Older Patients With Advanced-Stage Classic Hodgkin Lymphoma: A Prospective, Multicenter, Single-Arm, Phase II Cohort of the German Hodgkin Study Group HD21 Trial.

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Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE): a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network.

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Related Experiment Video

Updated: May 28, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

[Proteins in haematology].

Ricarda E Clarenbach1, Ulrich Mey

  • 1Medizinische Onkologie und Hämatologie, Departement Innere Medizin, Kantonsspital Graubünden, Chur. ricarda.clarenbach@ksgr.ch

Therapeutische Umschau. Revue Therapeutique
|November 3, 2011
PubMed
Summary

Monoclonal antibodies like rituximab have revolutionized blood cancer treatment, offering new options for non-Hodgkin

Area of Science:

  • Hematology
  • Oncology
  • Immunotherapy

Background:

  • Monoclonal antibodies represent a significant advancement in treating hematologic neoplasms.
  • The CD20 antibody rituximab is a key therapy for CD20-positive B-cell non-Hodgkin's lymphoma (NHL) and follicular lymphoma maintenance.
  • Rituximab is also used for non-malignant conditions like immune thrombocytopenia.

Purpose of the Study:

  • To review the impact and evolution of monoclonal antibodies in hematologic neoplasm treatment.
  • To highlight current and emerging antibody-based therapies for various hematologic malignancies.

Main Methods:

  • Review of existing literature on monoclonal antibody therapies in hematology.
  • Analysis of the clinical applications and efficacy of antibodies such as rituximab, alemtuzumab, ofatumumab, ibritumomab-tiuxetan, and brentuximab vedotin.

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Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

Related Experiment Videos

Last Updated: May 28, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

Main Results:

  • Rituximab is a cornerstone therapy in NHL and follicular lymphoma, with established maintenance protocols.
  • Other antibodies like alemtuzumab, ofatumumab, and ibritumomab-tiuxetan are used for specific conditions like CLL and refractory lymphomas.
  • Brentuximab vedotin shows high activity in Hodgkin's lymphoma and anaplastic large cell lymphoma.

Conclusions:

  • Monoclonal antibodies have transformed hematologic cancer treatment, offering targeted therapies.
  • The pipeline for new antibody approvals suggests continued innovation in this field.
  • Antibody-based treatments are crucial for both malignant and some non-malignant hematologic diseases.