Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The goal of specificity in psychotropic drug development: A lesson from Sisyphus?

Journal of psychopharmacology (Oxford, England)·2026
Same author

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Evaluation of the impact of low activity imaging in [<sup>11</sup>C]-(+)-PHNO and [<sup>11</sup>C]UCB-J PET-MR scans.

EJNMMI physics·2026
Same author

Medicines for Anxiety: A Hundred Years of Tranquillity and More to Come?

Human psychopharmacology·2026
Same author

A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial.

Nature medicine·2026
Same author

Drug harms in Canada: A multi-criteria decision analysis.

Journal of psychopharmacology (Oxford, England)·2026

Related Experiment Video

Updated: May 28, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Low serotonergic tone and elevated risk for substance misuse.

David Nutt

    The British Journal of Psychiatry : the Journal of Mental Science
    |November 3, 2011
    PubMed
    Summary

    This study investigates neurotransmitter interactions in brain function, a topic with limited current evidence. Further research is needed to determine potential applications for treating substance dependence.

    Area of Science:

    • Neuroscience
    • Neurochemistry

    Background:

    • The interplay of neurotransmitters is hypothesized as central to brain function.
    • Empirical evidence supporting this hypothesis remains scarce.

    Discussion:

    • This paper presents novel findings on neurotransmitter interactions.
    • The study's implications for understanding brain mechanisms are discussed.

    Key Insights:

    • New evidence emerges regarding the complex interactions between different neurotransmitters.
    • The research provides a foundation for future studies in neurobiology.

    Outlook:

    • Further investigation is required to explore the therapeutic potential for substance use disorders.
    • The findings may pave the way for new treatment strategies for addiction.

    More Related Videos

    Developing a Rat Model for Bipolar Disorder
    04:42

    Developing a Rat Model for Bipolar Disorder

    Published on: May 2, 2025

    Related Experiment Videos

    Last Updated: May 28, 2026

    A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
    07:51

    A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

    Published on: June 18, 2018

    Developing a Rat Model for Bipolar Disorder
    04:42

    Developing a Rat Model for Bipolar Disorder

    Published on: May 2, 2025