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Related Experiment Video

Updated: May 28, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Medical therapy for premature ejaculation.

Amar Mohee1, Ian Eardley

  • 1Pyrah Department of Urology, St James University Hospital, Leeds, UK.

Therapeutic Advances in Urology
|November 3, 2011
PubMed
Summary
This summary is machine-generated.

Premature ejaculation (PE) is a common male sexual dysfunction. New treatments like dapoxetine and PSD502 offer improved efficacy and safety for managing PE, increasing intravaginal ejaculation latency time (IELT).

Keywords:
male sexual dysfunctionmedical therapymedical treatmentpremature ejaculation

Related Experiment Videos

Last Updated: May 28, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Andrology
  • Pharmacology

Background:

  • Premature ejaculation (PE) is a prevalent male sexual dysfunction.
  • Historically, a lack of standardized definition hindered research until the International Society of Sexual Medicine (ISSM) definition in 2009.
  • Various medical therapies exist, but evidence is strongest for selective serotonin reuptake inhibitors (SSRIs) and topical creams.

Purpose of the Study:

  • To review current and emerging medical therapies for premature ejaculation (PE).
  • To evaluate the efficacy and side effect profiles of available and upcoming PE treatments.
  • To highlight advancements in managing PE based on the ISSM definition.

Main Methods:

  • Literature review of medical therapies for premature ejaculation (PE).
  • Analysis of treatment efficacy, focusing on intravaginal ejaculation latency time (IELT) and patient satisfaction.
  • Comparison of side effect profiles for different drug classes and topical agents.

Main Results:

  • Selective serotonin reuptake inhibitors (SSRIs) and topical creams show the most convincing evidence for increasing IELT.
  • Daily SSRIs like paroxetine are effective but have significant side effects.
  • Dapoxetine, an on-demand SSRI, is licensed for PE treatment, offering a 2.5-3 fold increase in IELT with tolerable side effects.
  • Topical aerosol PSD502 is anticipated for licensing, potentially increasing IELT up to 6-fold with minimal side effects.

Conclusions:

  • The ISSM definition has advanced PE research and treatment.
  • Dapoxetine represents a significant advancement as a licensed, on-demand treatment for PE.
  • Emerging treatments like PSD502 show promise for improved efficacy and safety in managing PE.