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Population attributable risk of unintentional childhood poisoning in Karachi Pakistan
Bilal Ahmed1, Zafar Fatmi, Amna R Siddiqui
1Department of Medicine, Aga Khan University, Karachi, Pakistan. bilal.ahmed@aku.edu
Insights
Unintentional childhood poisoning is largely preventable. Key risk factors like unsafe storage of chemicals and socioeconomic status contribute significantly, highlighting the need for targeted prevention strategies in Pakistan.
Area of Science:
- Pediatric Toxicology
- Public Health Research
- Environmental Health
Background:
- Childhood poisoning poses a significant public health burden.
- Identifying population attributable risk (PAR) factors is crucial for effective prevention strategies.
- Understanding modifiable risk factors can guide targeted interventions.
Purpose of the Study:
- To determine the population attributable risk (PAR) of unintentional childhood poisoning.
- To identify key modifiable risk factors associated with childhood poisoning in a Pakistani population.
- To inform public health policies for poisoning prevention.
Main Methods:
- A hospital-based, matched case-control study was conducted.
- 120 cases of unintentional poisoning were compared with 360 controls.
- Population attributable risks (PARs) were calculated for identified risk factors.
Main Results:
- Significant PARs were observed for unsafe storage of chemicals (12%), hyperactivity (19%), storing fuel in beverage bottles (40%), low socioeconomic status (48%), and maternal lack of education (38%).
- Overall, 48% of poisoning cases were attributable to at least one of the six studied risk factors.
- Approximately half of all unintentional childhood poisoning cases in this population could potentially be avoided.
Conclusions:
- Potentially modifiable risk factors account for a substantial proportion of unintentional childhood poisoning cases.
- Findings underscore the significant potential for primary prevention of childhood poisoning in Pakistan.
- Interventions targeting unsafe storage, socioeconomic factors, and education are recommended.
Background:
The percentage of unintentional childhood poisoning cases in a given population attributable to specific risk factors (i.e., the population attributable risk) which can be calculated; determination of such risk factors associated with potentially modifiable risk factors, are necessary to focus on the prevention strategies.
Methods:
We calculated PARs, using 120 cases with unintentional poisoning and 360 controls in a hospital based matched case- control study. The risk factors were accessibility to hazardous chemicals and medicines due to unsafe storage, child behavior reported as hyperactive, storage of kerosene and petroleum in soft drink bottles, low socioeconomic class, less education of the mother and the history of previous poisoning.
Results:
THE FOLLOWING ATTRIBUTED RISKS WERE OBSERVED: 12% (95% confidence interval [CI] = 8%-16%) for both chemicals and medicines stored unsafe, 19% (15%-23%) for child reported as hyperactive, 40% (38%-42%) for storage of kerosene and petroleum in soft drink bottles, 48% (42%-54%) for low socioeconomic status, 38% (32%-42%) for no formal mothers education and 5.8% (2%-10%) for history of previous poisoning. 48% of cases for overall study population which could be attributed to at least one of the six risk factors. Among girls, this proportion was 23% and 43% among boys. About half of the unintentional childhood poisoning cases in this Pakistani population could be avoided.
Conclusion:
Exposure to potentially modifiable risk indicators explained about half of the cases of unintentional poisoning among children under five years of age in this Pakistani population, indicating the theoretical scope for prevention of the disease.
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