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Updated: May 28, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Pharmacogenetics and age-related macular degeneration
Stephen G Schwartz1, Milam A Brantley
1Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 311 9th Street North, No. 100, Naples, FL 34102, USA.
Abstract:
Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age-related macular degeneration. Most reported data concern polymorphisms in the complement factor H and age-related maculopathy susceptibility 2 genes. At this time, the data are not consistent and no definite conclusions may be drawn. As clinical trials data continue to accumulate, these relationships may become more apparent.
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