Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

Heart Failure Drugs: Diuretics

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products.

Cardiovascular therapeutics·2020

Same author

The role of echocardiography and 99mTc-HDP scintigraphy in non-invasive diagnosis of cardiac amyloidosis: A case series and literature review.

Medicine·2019

Same author

Anticoagulation in chronic kidney disease: from guidelines to clinical practice.

Clinical cardiology·2019

Same author

Morphological and functional renovascular changes as cause of resistant arterial hypertension - case report and literature review.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie·2018

Same author

Amyloidosis - a rare cause of refractory heart failure in a young female.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie·2017

Same author

THE "DARK SIDE" OF DEEP VEIN THROMBOSIS--CASE REPORT.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2016

Same journal

Antioxidant Activity of Essential Oil From Carum Carvi L. Cultivated in North-Eastern Romania.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Assessment of In Vitro Antioxidant activity of Some New Ferulic Acid Derivatives.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Fast RP-HPLC Method for the Determination of Bisoprolol.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

In Vitro Dissolution Studies of Amiodarone Hydrochloride From Hydroxy-Propyl-β-Cyclodextrin/Amiodarone Inclusion Complex Formulated Into Modified-Release Tablets.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Esthetic Rehabilitation Through CAD/CAM Technology - Case Report.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Correlation Among Chronological Age, Dental Age and Cervical Vertebrae Maturity in Romanian Subjects.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

A Mouse 5/6^th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

[Cardiorenal syndrome].

Viviana Aursulesei¹, A Cozma, M D Datcu

¹Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicină, Clinica I Medicală Cardiologică.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|November 4, 2011

Summary

This summary is machine-generated.

Cardiac and renal disease frequently coexist, leading to cardiorenal syndrome. This review clarifies the complex pathophysiology, diagnosis, and treatment of this deadly association.

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Related Experiment Videos

Last Updated: May 28, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

A Mouse 5/6^th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Area of Science:

Cardiology
Nephrology
Internal Medicine

Context:

Cardiac and renal diseases often coexist, increasing mortality and healthcare costs.
The cardiorenal syndrome describes the heart-kidney interaction, lacking a consensus definition.
Limited data exist on incidence, pathophysiology, and diagnostic criteria for cardiorenal syndrome.

Purpose:

To provide a comprehensive overview of the cardiorenal relationship.
To elucidate the complex pathophysiology, epidemiology, diagnosis, and treatment of cardiorenal syndrome.
To offer clearer perspectives on future therapeutic strategies for this condition.

Summary:

This paper reviews the multifaceted aspects of cardiorenal syndrome.
It addresses the intricate interactions between cardiac and renal systems.
The review covers pathophysiology, epidemiology, diagnostics, and treatment challenges.

Impact:

Aims to improve understanding and management of cardiorenal syndrome.
Highlights the need for standardized definitions and diagnostic criteria.
Informs future therapeutic approaches for this deadly cardiorenal association.