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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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[Morphopathological changes in glaucoma-induced trabecular meshwork].

D Petraru1, Anca Indrei, D Costin

  • 1Universităţii de Medicină şi Farmacie "Gr.T. Popa" Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|November 4, 2011
PubMed
Summary
This summary is machine-generated.

Glaucoma involves changes in the trabecular meshwork and Schlemm canal, obstructing aqueous humor flow. Histological analysis of surgically removed tissues revealed diverse pathological changes contributing to this obstruction.

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Area of Science:

  • Ophthalmology
  • Histopathology

Context:

  • Glaucoma is characterized by increased intraocular pressure.
  • The trabecular meshwork and Schlemm canal are critical for aqueous humor drainage.
  • Pathological changes in these structures impede aqueous outflow.

Purpose:

  • To investigate the histological alterations in trabecular meshwork tissues obtained from glaucoma patients undergoing surgery.
  • To correlate observed histological changes with aqueous humor flow obstruction.

Summary:

  • Surgically excised trabecular meshwork tissues were subjected to histological examination.
  • Key findings included ordered structures with high eosinophilia (29.87%), rare structures with high eosinophilia (20.12%), voluminous trabecular meshwork with fusiform cells (21.34%), tissue fibrosis (21.03%), and tissue necrosis (7.62%).
  • These diverse histological changes were present in all analyzed specimens.

Impact:

  • Demonstrates that specific histological changes within the trabecular meshwork are consistently associated with aqueous humor flow obstruction in glaucoma.
  • Provides a detailed histopathological basis for understanding the mechanisms of aqueous outflow resistance in glaucoma.
  • Highlights the importance of trabecular meshwork integrity for maintaining normal intraocular pressure.