Preparation, characterization and application of chitosan-alginate based polyelectrolyte complex as fast...

Present investigation was carried out with aim to synthesize chitosan-alginate polyelectrolyte complex, their characterization and then formulation of phenytoin sodium fast dispersible tablet using polyelectrolyte as active excipient.

In this study, polyelectrolyte complex was formed by ionic cross-linking of polymers. Dried complex was evaluated for micromeritic properties and flow behaviour. Tablets were prepared for six batches based on different proportion of complex viz 5%, 10%, 20%, 30%, 40%, 50% and 60%. Tablets were evaluated for hardness, friability, thickness, in vitro disintegration time, in vitro dissolution study and stability study.

Results of micromeritic study and flow behaviour predict that complex can be used as an efficient excipient. Hardness, friability, thickness all were in acceptable limit. Release studies were showed that tablets release drug up to 99.97%. Batch showed .sec of invitro disintegration time. Stability study easily predicted that formulation characteristics dose not changed during the whole period of study.

From the findings it is concluded that chitosan-alginate polyelectrolyte complex is efficient excipient for fast dispersible formulation especially required in case of epilepsy and chronic diseases.