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MMP7 -181G allele is a low-penetrant risk factor for cancer development in East Asians

Mi Yuan-Yuan1, Zhang Li-Feng, Zhu Li-Jie

  • 1Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, China. miniao1984@163.com

DNA and Cell Biology
|November 4, 2011
PubMed

Insights

The MMP7 -181A/G polymorphism is linked to increased cancer risk in East Asian populations. This meta-analysis suggests the -181 G allele may elevate cancer susceptibility in this demographic.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme implicated in tumor invasion, metastasis, and cancer survival.
  • Previous studies on the association between MMP7 genetic variations and cancer risk have yielded conflicting results due to limited statistical power.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the relationship between the MMP7 -181A/G polymorphism and cancer risk.
  • To assess the impact of the MMP7 -181A/G polymorphism on cancer risk specifically within the East Asian population.

Main Methods:

  • A meta-analysis was performed on 14 publications comprising 16 case-control studies.
  • Studies were identified through a systematic search of the PubMed database.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between the MMP7 -181A/G polymorphism and cancer risk.

Main Results:

  • The -181 G allele was found to significantly increase cancer risk in East Asians (G-allele vs. A-allele: OR=1.35, 95% CI: 1.25-1.46).
  • Stratified analyses by cancer type and control source also indicated a significantly increased cancer risk associated with this polymorphism.
  • Specific genotype comparisons (GA vs. AA and GG+GA vs. AA) further supported the increased risk.

Conclusions:

  • The MMP7 -181A/G polymorphism is associated with an increased risk of cancer in the East Asian population.
  • Further research with larger sample sizes is recommended to validate these findings and explore the association in greater detail.

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