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Related Experiment Videos

Low-dose aspirin for migraine prophylaxis.

J E Buring1, R Peto, C H Hennekens

  • 1Department of Medicine, Harvard Medical School, Boston, Mass.

JAMA
|October 3, 1990
PubMed
Summary

Low-dose aspirin therapy significantly reduced migraine recurrence by 20% in a large clinical trial. This suggests aspirin

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Trials

Background:

  • Migraine is a common neurological disorder.
  • Platelet activation is implicated in migraine pathophysiology.
  • Preventive treatments for migraine are needed.

Purpose of the Study:

  • To investigate the efficacy of low-dose aspirin in preventing migraine recurrence.
  • To explore the role of platelets in migraine.

Main Methods:

  • Physicians' Health Study: a randomized, double-blind, placebo-controlled trial.
  • 22,071 US male physicians aged 40-84 years.
  • Low-dose aspirin (325 mg every other day) vs. placebo for 60 months.

Main Results:

  • Aspirin group: 6.0% reported migraine vs. 7.4% in placebo group.
  • Statistically significant 20% reduction in migraine recurrence with aspirin.
  • No difference in ordinary headache rates between groups.

Conclusions:

  • Low-dose aspirin significantly reduces migraine recurrence.
  • Migraine pathophysiology involves platelet effects.
  • Low-dose aspirin may be considered for migraine prophylaxis.

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