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Antibody-targeted thrombolytic agents
E Haber1, T Quertermous, G R Matsueda
1Cardiac Unit, Massachusetts General Hospital, Boston 02114.
Japanese Circulation Journal
|April 1, 1990
Abstract:
Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of immunology, molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.