Related Experiment Video
Updated: May 28, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and
Abigail A Marsh1, Elizabeth C Finger2, Katherine A Fowler3
1Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA; Department of Psychology, Georgetown University, Washington DC, USA.
Abstract:
We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.
More Related Videos
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
06:42Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
Published on: September 28, 2018
Related Concept Videos
Conduct Disorder
Antisocial Personality Disorder
Behavioral Characteristics and...
Oppositional Defiant Disorder
Diagnostic Criteria and...
Dark Triad and Person Perception
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Causes of Social Behavior II: Cognitive Processes