Related Experiment Video
Updated: May 28, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Perinatal risk factors for bronchopulmonary dysplasia in extremely low gestational age infants: a pregnancy
Xavier Durrmeyer1, Gilles Kayem, Martine Sinico
1Department of Neonatology, Centre Hospitalier Intercommunal de Créteil, Créteil, France. xavier.durrmeyer@chicreteil.fr
Objective:
To analyze risk factors for bronchopulmonary dysplasia (BPD) or death according to the condition leading to extremely preterm birth, preterm labor, or vascular disorders.
Study Design:
Retrospective study of all premature births before 28 weeks of gestation in a single Level III institution. Mother/infants were attributed to the "preterm labor" or "vascular disorder" group according to the condition leading to delivery. Characteristics and outcomes were compared between groups. Independent risk factors for BPD or the composite outcome "BPD or death" were identified within each group.
Results:
Three hundred ninety-six infants from 349 pregnancies were characterized for perinatal characteristics. BPD was significantly more frequent in the vascular disease group than in the preterm labor group (29% vs 11%, P < .01). Independent risk factors of BPD were a low gestational age in the preterm labor group and severe growth restriction in the vascular disease group.
Conclusion:
Classification of preterm birth according to the condition leading to delivery might help to reduce confounding of risk factors for BPD. Intrauterine vascular disorders are significantly associated with BPD.
Related Concept Videos
Chronic Obstructive Pulmonary Disease I: Introduction
Pulmonary Cycle: Exhalation
Other Pulmonary Disorders
Breathing
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features