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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis following intravitreal injections
Cristina Irigoyen1, Kimia Ziahosseini, George Morphis
1Link 8z, St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK.
Summary
Endophthalmitis following intravitreal injections is rising, with poor visual outcomes despite antibiotic treatment. Clinical features did not reliably predict culture-negative cases in this study.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Endophthalmitis is a serious complication following intravitreal injections.
- The incidence of post-injection endophthalmitis has increased.
- Understanding clinical features and outcomes is crucial for management.
Purpose of the Study:
- To analyze clinical features, culture results, management strategies, and visual outcomes.
- To assess the effectiveness of intravitreal antibiotics in treating endophthalmitis.
- To identify predictors of culture-negative endophthalmitis.
Main Methods:
- Retrospective review of patients treated for endophthalmitis after intravitreal injections.
- Analysis of aqueous or vitreous biopsy results and culture data.
- Evaluation of treatment regimens including intravitreal antibiotics and surgical interventions.
Main Results:
- Culture-positive endophthalmitis involved Staphylococcus, Streptococcus, E. coli, and gram-negative bacilli.
- Symptoms typically appeared within 48 hours; pain was not always present.
- Visual acuity outcomes were poor, with 9/19 patients having vision of 6/60 or worse.
Conclusions:
- The incidence of endophthalmitis post-intravitreal injection is increasing.
- Current treatment strategies yield relatively poor visual outcomes.
- Clinical features are not reliable indicators for identifying culture-negative endophthalmitis.
