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Fiber-delivered picosecond source for coherent Raman scattering imaging
1School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA. kw376@cornell.edu
Optics Letters
|November 4, 2011
Summary
We developed a fiber-delivered picosecond laser source for advanced coherent Raman scattering (CRS) imaging. This practical system enables high-resolution biological tissue imaging, demonstrating its potential for scientific applications.
Area of Science:
- Optics and Photonics
- Biomedical Imaging
- Laser Physics
Background:
- Coherent Raman scattering (CRS) imaging offers label-free visualization of biological tissues.
- Existing CRS systems often require complex setups and bulky components.
- Development of compact and efficient light sources is crucial for advancing CRS microscopy.
Purpose of the Study:
- To demonstrate a novel two-color, fiber-delivered picosecond laser source for CRS imaging.
- To showcase the system's capability for practical biological imaging applications.
Main Methods:
- A wavelength-tunable picosecond pump was generated via nonlinear spectral compression of a femtosecond pulse from a mode-locked titanium:sapphire (Ti:S) laser.
- A 1064 nm picosecond Stokes pulse was produced using an all-fiber time-lens source synchronized to the Ti:S laser.
- Pump and Stokes beams were combined in an optical fiber coupler, acting as both delivery and nonlinear spectral compression medium.
Main Results:
- Successful generation of a two-color, fiber-delivered picosecond source.
- Demonstration of CRS imaging of mouse skin.
- The integrated fiber optic system proved effective for spectral compression and beam delivery.
Conclusions:
- The developed fiber-based picosecond source is practical for coherent Raman scattering imaging.
- This compact system simplifies CRS instrumentation and enhances its applicability in biological research.
- Further advancements in fiber laser technology can significantly impact label-free imaging modalities.
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