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Serglycin: a structural and functional chameleon with wide impact on immune cells
Svein O Kolset1, Gunnar Pejler
1Department of Nutrition, University of Oslo, 0316 Oslo, Norway. s.o.kolset@medisin.uio.no
Abstract:
Among the different proteoglycans expressed by mammals, serglycin is in most immune cells the dominating species. A unique property of serglycin is its ability to adopt highly divergent structures, because of glycosylation with variable types of glycosaminoglycans when expressed by different cell types. Recent studies of serglycin-deficient animals have revealed crucial functions for serglycin in a diverse array of immunological processes. However, its exact function varies to a large extent depending on the cellular context of serglycin expression. Based on these findings, serglycin is emerging as a structural and functional chameleon, with radically different properties depending on its exact cellular and immunological context.
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