Related Experiment Video
Updated: May 27, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Components of the Anger-hostility Complex as Risk Factors for Coronary Artery Disease Severity: A Multi-measure Study
M R McDermott1, J M Ramsay, C Bray
1University of East London, UK.
Insights
Expressed anger, not other hostility types, strongly predicts coronary artery disease (CAD). Smoking and age also impact disease severity, suggesting focused research on anger expression
Area of Science:
- Cardiology
- Psychosomatic Medicine
- Behavioral Medicine
Background:
- Anger and hostility are linked to coronary artery disease (CAD) pathogenesis.
- Previous research has not comprehensively assessed various anger/hostility forms in a single study.
- Understanding the specific roles of different anger expressions is crucial for CAD etiology.
Purpose of the Study:
- To evaluate the relative predictive utility of multiple anger and hostility measures in relation to CAD.
- To identify which specific anger/hostility variables are most significantly associated with coronary artery disease.
- To guide future research by pinpointing key etiological factors in CAD.
Main Methods:
- A multi-measure study involving three adult outpatient groups.
- Participants included men with angiographically confirmed CAD, men with valvular heart disorders, and men attending a fracture clinic (no CAD).
- Questionnaires assessed anger expression, anger experience, cynical hostility, 'Ho' hostility, neurotic hostility, neurotic disagreeableness, resentment, and suspiciousness.
Main Results:
- Expressed anger emerged as the most significant correlate of CAD.
- Years as a smoker and advanced age were also independently related to CAD severity.
- Seven other anger/hostility variables showed no significant predictive utility comparable to expressed anger.
Conclusions:
- Expressed anger is a primary anger-hostility correlate in coronary artery disease etiology.
- Further investigation is needed to identify the specific toxic components of expressed anger and relevant socio-occupational environments.
- Research should focus on the mechanisms linking expressed anger to CAD and contextual factors influencing its occurrence.
Abstract:
Different forms of anger and hostility have been implicated in the pathogenesis of coronary artery disease (CAD), though previous research has not measured all of these in one sample. To assess their relative predictive utility, a multi-measure study was undertaken of three adult outpatient groups: 97 men identified angiographically with stenosed coronary arteries; 28 men with valvular heart disorders in the absence of CAD; and 28 men attending a fracture clinic with no CAD present. Questionnaires measured: anger expression; anger experience; cynical hostility; 'Ho' hostility; neurotic hostility; neurotic disagreeableness; resentment; and suspiciousness. The pre-eminent anger-hostility correlate of CAD was found to be expressed anger, with years as a smoker and age also being independently related to disease severity. Thus, seven of these anger/hostility variables do not warrant similar attention as anger expression in CAD aetiology. Further research should identify coronary toxic components of anger expression and of socio-occupational environments that afford or constrain their occurrence.
Related Concept Videos
Coronary Artery Disease I: Introduction
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease IV: Preventive Measures
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease III: Clinical Manifestations
