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Related Concept Videos

Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
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Related Experiment Video

Updated: Jun 28, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

[Respiratory function in cardiopulmonary transplantation].

A T Dinh Xuan1

  • 1Laboratoire d'Explorations Fonctionnelles, Hôpital Cochin, Saint-Jacques, Paris.

Revue Des Maladies Respiratoires
|January 1, 1990
PubMed
Summary

Heart-lung transplantation (HLT) research suggests pulmonary afferents have a minimal role in resting breathing control in adults. However, HLT patients show bronchial hyperreactivity, potentially linked to lung rejection.

Area of Science:

  • Pulmonary physiology
  • Transplantation research
  • Neuroscience

Context:

  • Heart-lung transplantation (HLT) offers a unique model for investigating human respiratory physiology.
  • HLT recipients, post-complication recovery, exhibit normal ventilatory function, blood gases, and exercise tolerance.
  • Understanding pulmonary innervation's role is crucial for respiratory control mechanisms.

Purpose:

  • To evaluate the role of pulmonary innervation in human respiratory control using HLT recipients.
  • To assess breathing control at rest, during sleep, and in response to stimuli like CO2 and exercise.
  • To investigate bronchial hyperreactivity and its potential links to lung rejection or cholinergic stimulation.

Summary:

  • HLT studies indicate pulmonary afferents play a negligible role in resting breathing control in adult humans.

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  • Ventilatory responses to CO2 and exercise in HLT subjects yield contradictory results, precluding firm conclusions on innervation's role.
  • Bronchial hyperreactivity to cholinergic stimulation is evident in HLT patients, possibly due to upregulated muscarinic receptors.
  • Increased bronchial response to distilled water in some HLT subjects may relate to lung rejection episodes.
  • HLT studies support the reflex theory of cough and offer insights into bronchomotor tone regulation.

    • Impact:

    • Findings suggest pulmonary afferents are not critical for resting respiratory control in adults.
    • HLT research highlights the role of bronchial hyperreactivity and potential links to lung rejection.
    • Further studies on reinnervation in HLT patients could enhance understanding of respiratory function and control.
    • This research contributes to a deeper comprehension of human respiratory physiology and its regulatory mechanisms.